Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children.

Activation of the CD95 (APO-l/Fas) System in T Cells From Human Immunodeficiency Virus Type-l -Infected Children

Increased apoptosis of CD4' T cells is considered to be involved in CD4' T-cell depletion in human immunodeficiency virus type-l (HIV-l)-infected individuals progressing toward acquired immunodeficiency syndrome [AIDS). We have recently shown that CD95 (APO-I/Fas) expression is strongly increased in T cells of HIV-l-infected children. In this report we provide further evidence for a deregulated...

Downregulation of increased CD95 (APO-1/Fas) ligand in T cells from human immunodeficiency virus-type 1-infected children after antiretroviral therapy.

RAPID COMMUNICATION Fas-Mediated Apoptosis of CD4+ and CD8+ T Cells From Human Immunodeficiency Virus-Infected Persons: Differential In Vitro Preventive Effect of Cytokines and Protease Antagonists

Human immunodeficiency syndrome (HIV) infection leads to a progressive loss of T-cell-mediated immunity associated with T-cell apoptosis. We report here that CD4’ and CD8’ T cells from HIV-l-infected persons are sensitive to Fas (CD95/APO-l)-mediated death induced either by an agonistic anti-Fas antibody or by the physiologic soluble Fas ligand, although showing no sensitivity to tumor necrosi...

T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)- mediated apoptosis of CD4+ T cells from human immunodeficiency virus- infected persons

Human immunodeficiency virus (HIV) infection leads to a progressive loss of CD4+ T helper (Th) type 1 cell-mediated immunity that is associated with defective in vitro CD4+ T cell proliferation and abnormal T cell death by apoptosis in response to T cell receptor (TCR) stimulation. Quantification of interleukin (IL)-2, interferon gamma, IL-4, IL-5, and IL-10 secretion by immunoassays, and of in...

Fas-mediated apoptosis of CD4+ and CD8+ T cells from human immunodeficiency virus-infected persons: differential in vitro preventive effect of cytokines and protease antagonists.

Human immunodeficiency syndrome (HIV) infection leads to a progressive loss of T-cell-mediated immunity associated with T-cell apoptosis. We report here that CD4+ and CD8+ T cells from HIV-1-infected persons are sensitive to Fas (CD95/APO-1)-mediated death induced either by an agonistic anti-Fas antibody or by the physiologic soluble Fas ligand, although showing no sensitivity to tumor necrosis...